Research
Lactobacillus crispatus CTV-05 for Bladder Health: Evidence, Interactions and Cautions
Lactobacillus crispatus CTV-05 is an ingredient used in bladder supplements marketed to women. Below is what it has actually been studied for, how strong that evidence is, the drug interactions and cautions on record, and the primary source our grade rests on — all drawn from the HerWellReport ingredient dataset.
Also sold as: CTV-05; Lactin-V
What the evidence says about Lactobacillus crispatus CTV-05
Route is the whole story here. Stapleton's phase 2 double-blind trial gave 100 premenopausal women with recurrent UTI an intravaginal Lactin-V suppository daily for 5 days then weekly for 10 weeks after treatment for cystitis: recurrent UTI occurred in 15% (7 of 48) on Lactin-V versus 27% (13 of 48) on placebo, a relative risk of 0.5 (95% CI 0.2 to 1.2). That confidence interval crosses 1, so the result did not reach statistical significance and it was a phase 2 study, not a confirmatory one. No trial has tested swallowing this strain for bladder outcomes, and it is not sold as a licensed medicine.
The grade "limited intravaginally; none orally" means: limited — One or two small human trials, or trials for a closely related outcome. none — No human trial evidence we could find for this use. Grades are explained in full on our methodology page.
Read the primary source this grade rests on (opens in a new tab).
Lactobacillus crispatus CTV-05 drug interactions
No documented drug interactions in the sources we checked. That is not the same as proof of safety alongside your medication — it usually means the question has not been studied. Ask a pharmacist before combining it with prescription drugs.
Who should be careful with Lactobacillus crispatus CTV-05
- Avoid if you are severely ill or immunocompromised: NCCIH reports infections and other serious harms are more likely in those groups
- the tested product is an investigational vaginal suppository, not an oral supplement on sale
Read more on HerWellReport
- Do Probiotics Actually Help Bladder Health?
- 65 Ingredients, None Proven: What Is Actually Inside the Supplements Sold to Women (2026)
- FemiCore vs AZO Bladder Control: Ingredients, Price and Guarantee Compared
- Is It Normal to Pee Every Hour? What Counts as Normal Urinary Frequency
- MenoRescue vs Provitalize: Ingredients, Price and Guarantee Compared
This entry is generated from row "Lactobacillus crispatus CTV-05" of the HerWellReport ingredient dataset (v2.1, updated 2026-09-23). The dataset is free to reuse under CC BY 4.0 — how to cite it. Ingredient evidence is not evidence for any finished product, and nothing here is medical advice.