Research
Melatonin for Menopause: Evidence, Interactions and Cautions
Melatonin is an ingredient used in menopause supplements marketed to women. Below is what it has actually been studied for, how strong that evidence is, the drug interactions and cautions on record, and the primary source our grade rests on — all drawn from the HerWellReport ingredient dataset.
Also sold as: N-acetyl-5-methoxytryptamine
What the evidence says about Melatonin
NCCIH rates the jet lag evidence as medium quality and says there is not enough strong evidence to recommend melatonin for chronic insomnia. A systematic review and meta-analysis of seven RCTs in 497 menopausal women found no significant improvement in sleep quality (PSQI standardised mean difference -0.87, 95% CI -1.94 to 0.19) and no significant effect on menopausal symptoms, with very high heterogeneity between trials. A possible bone density signal came only from trials where melatonin was combined with calcium, vitamin D or strontium, so it cannot be attributed to melatonin. Melatonin is absent from the Menopause Society's 2023 nonhormone therapy position statement.
The grade "limited for sleep; very limited in menopause" means: very limited — Mostly animal, laboratory or anecdotal evidence, with at most a single weak human study. Grades are explained in full on our methodology page.
Read the primary source this grade rests on (opens in a new tab).
Melatonin drug interactions
- Anticoagulants (blood thinners)
Who should be careful with Melatonin
- Long-term safety is not established
- people with epilepsy and anyone on anticoagulants should use it only under medical supervision
- product content is unreliable, with 22 of 25 melatonin gummies in a 2023 analysis mislabelled at 74-347% of the stated dose
Read more on HerWellReport
- Best Menopause Supplements: What Is Actually In Them
- 65 Ingredients, None Proven: What Is Actually Inside the Supplements Sold to Women (2026)
This entry is generated from row "Melatonin" of the HerWellReport ingredient dataset (v2.1, updated 2026-09-23). The dataset is free to reuse under CC BY 4.0 — how to cite it. Ingredient evidence is not evidence for any finished product, and nothing here is medical advice.