Research

Vitamin E for Menopause: Evidence, Interactions and Cautions

By Andreea · Last reviewed September 2026 · 2 min read

Vitamin E is an ingredient used in menopause supplements marketed to women. Below is what it has actually been studied for, how strong that evidence is, the drug interactions and cautions on record, and the primary source our grade rests on — all drawn from the HerWellReport ingredient dataset.

HerWellReport Evidence Gradelimited

Studied forHot flushes and night sweats in menopausal women and in breast cancer survivors; also taken generally as an antioxidant

Used inMenopause supplements

Helps stress leaks?No

Helps hot flushes?No

Also sold as: Alpha-tocopherol; tocopherol

What the evidence says about Vitamin E

The Menopause Society's 2023 nonhormone therapy position statement reviewed two crossover trials (120 and 50 women) and found only a limited reduction in hot flush frequency compared with placebo. Those trials were small, short and crossover in design, so the small difference is hard to separate from placebo response. Vitamin E is named explicitly on that statement's not-recommended list, at Level I.

The grade "limited" means: limited — One or two small human trials, or trials for a closely related outcome. Grades are explained in full on our methodology page.

Read the primary source this grade rests on (opens in a new tab).

Vitamin E drug interactions

Warfarin and other anticoagulants or antiplatelets
niacin plus statin combinations
chemotherapy and radiotherapy

Who should be careful with Vitamin E

High doses increase bleeding risk
do not exceed the tolerable upper intake level of 1,000 mg/day of supplemental alpha-tocopherol
ask an oncologist before using antioxidant supplements during chemotherapy or radiotherapy

Vitamin E for Menopause: Evidence, Interactions and Cautions

What the evidence says about Vitamin E

Vitamin E drug interactions

Who should be careful with Vitamin E

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