Menopause

O Positiv MENO Review: The Capsule and the Gummy Aren’t the Same Dose

By Andreea · Last reviewed October 2026 · 8 min read

Woman in her 50s browsing a drugstore shelf, considering menopause supplements

O Positiv’s MENO is one of the most widely distributed menopause supplements in the country — it is sold at Target, CVS and, since April 2025, more than 2,000 Walmart stores⁵. It comes in two formats, capsule and gummy, built around the same three “hormone-free” botanicals: black cohosh, ashwagandha and chasteberry. We checked the label against the actual trial evidence for each ingredient, and found three different stories hiding under one marketing claim. Short on time? Skip to what we’d look at instead →

What MENO actually is

MENO is made by O Positiv, a women’s-health brand founded by siblings Brianna and Bobby Bitton that also sells FLO (PMS), URO (urinary and vaginal health) and several other category products. The capsule version of MENO launched first, in May 2022; the gummy version followed in January 2023⁶. Both are marketed as hormone-free relief for hot flashes, night sweats, occasional sleeplessness and mood changes. The brand has grown fast — it is now carried at Target, CVS and Walmart, and leans heavily on TikTok for consumer education⁵, which is part of why it shows up in so many searches and so few independent reviews.

The label is genuinely disclosed, which is rarer than it should be in this category. Per two capsules (or two gummies) a day, the supplement facts panels list: ashwagandha (KSM-66 root extract), black cohosh, chasteberry extract, vitamin B6 and vitamin D3. The amounts are printed, not hidden behind a proprietary blend. That alone puts MENO ahead of several products we’ve reviewed that won’t say how much of anything is in the bottle. The question is whether the amounts printed are the amounts that were actually studied.

The capsule and the gummy are not the same dose

This is the finding worth leading with. Comparing the two products’ own published supplement facts panels side by side:

Ingredient (per 2 capsules / 2 gummies)	MENO Capsules	MENO Gummies
Ashwagandha (KSM-66)	300 mg	150 mg
Black cohosh	40 mg	40 mg
Chasteberry extract	40 mg	40 mg
Vitamin B6	2 mg	2 mg
Vitamin D3	15 mcg	15 mcg

Black cohosh, chasteberry, B6 and D3 are identical across both formats. Ashwagandha is not — the gummy carries exactly half the capsule’s dose. Both products are marketed on the same page, under the same claims, with the same “2 a day” instruction⁶, and nothing in the marketing we could find flags that switching formats cuts your ashwagandha intake in half. If you started on capsules and moved to gummies for convenience — or bought whichever was in stock at Walmart that week — you would not know your dose had changed.

Three ingredients, three different evidence problems

MENO is sold as a single hormone-free solution, but its three active botanicals don’t share one evidence story. Each has its own, and none of them is “this combination has been tested and works.”

Ashwagandha: a real trial, at double the gummy’s dose

Of the three ingredients, ashwagandha has the most directly relevant trial. A randomized, double-blind, placebo-controlled study of 100 perimenopausal women (91 completed) gave the KSM-66 extract — the same branded extract MENO uses — at 600 mg per day for eight weeks. The ashwagandha group saw a significantly larger improvement on the Menopause Rating Scale than placebo, along with fewer hot flashes and improvements in mood and quality of life⁴. That is a genuinely encouraging single trial, not proof, but a real signal worth taking seriously.

MENO’s capsule dose is 300 mg — half the dose used in that trial. The gummy dose is 150 mg — a quarter of it. Neither format delivers the amount that produced the result the ingredient’s own best evidence is based on. The NIH’s Office of Dietary Supplements also notes that ashwagandha has been linked to liver injury in some people, may affect thyroid function, and can interact with thyroid medication, diabetes and blood pressure medication, sedatives, and immunosuppressants — and isn’t considered safe in pregnancy³.

Black cohosh: the dose is standard, the evidence is weak regardless

Black cohosh is the one ingredient in this formula that actually has a track record in hot-flash research — and the track record isn’t good. A 2012 Cochrane review covering 16 randomized trials and over 2,000 women found insufficient evidence to support or oppose it for menopausal symptoms, and a later meta-analysis found no significant effect on vasomotor symptoms. The North American Menopause Society advises against recommending it, and the American College of Obstetricians and Gynecologists states the data don’t show it works¹. The trials used daily doses from 8–160 mg, with a median of 40 mg — which is exactly what MENO uses, so the dose isn’t the problem here. The ingredient’s own evidence base is. On safety, roughly 83 cases of liver injury have been reported worldwide in association with black cohosh use, though a causal link hasn’t been established¹.

Chasteberry: not actually studied for this

This is the one most worth knowing before you buy. Chasteberry (vitex) has real clinical evidence — for premenstrual syndrome and cyclical breast pain in women with regular cycles, aged roughly 20–40. It is not a menopause herb. Memorial Sloan Kettering’s integrative medicine reference notes that the one study testing chasteberry (alongside St. John’s wort) for menopausal symptoms specifically found it did not help². Putting it in a menopause formula borrows the ingredient’s reputation from a completely different use case. It also carries interactions worth knowing about: chasteberry may interfere with dopamine-agonist medications (used for Parkinson’s disease and some pituitary conditions), may reduce the effectiveness of hormonal contraceptives, and inhibits two liver enzymes (CYP2C19 and CYP3A4) that metabolize other drugs².

None of this means the formula “doesn’t work” in a way we could prove — we haven’t tested it, and nobody has published a trial of MENO itself, as opposed to its individual ingredients. It means the honest-broker reading of this label is: one ingredient has a decent single trial behind it (undercut by the dose), one is already written off by the people who study it, and one isn’t aimed at this use at all.

Price and where it’s sold

MENO capsules have been sold at around $36.99 for a 60-count bottle — a 30-day supply at two a day — with multi-bottle bundles offering a modest per-bottle discount and a subscription option through the brand’s own site. The gummies are priced similarly per bottle. It’s carried at Target, CVS and Walmart in addition to the brand’s direct-to-consumer site, so pricing can vary slightly by retailer and by whatever promotion is running. We’d recommend checking the current price at whichever retailer you’d actually buy from rather than relying on any number in a review, including this one — prices on nationally distributed supplements move.

We could not independently verify a published money-back guarantee for MENO at the time of writing. If you buy from a retailer like Target, Walmart or CVS rather than directly from the brand, that retailer’s own return policy — not a supplement-specific guarantee — is what governs a refund, and typically requires the item to be in its original condition within the retailer’s standard return window. Worth checking before you buy a multi-bottle bundle.

Short on time? What we’d look at instead

If you’re weighing a hormone-free menopause supplement, the honest summary is that this entire category — not just MENO — sits in the North American Menopause Society’s 2023 “not recommended” bucket for herbal and dietary supplements as a class, because the trial evidence for hot flashes specifically hasn’t held up⁷. That doesn’t make every ingredient worthless (ashwagandha’s single trial above is a real, if early, signal), but it does mean no supplement in this space — including the one we have an affiliate relationship with — should be presented as a proven fix.

We publish no star ratings, no testimonials, and no invented comparisons on this site — including here. If you want to see how we evaluate our own affiliate product with the same scrutiny, including its dose disclosures and what its guarantee actually covers, our MenoRescue review lays it out the same way.

See MenoRescue’s current price →

We earn a commission if you buy through this link, at no extra cost to you. We were not paid to write this article and were not given free product by O Positiv or by WellMe (MenoRescue’s maker).

Bottom line

O Positiv MENO deserves credit for publishing its actual doses — most competitors in this category won’t. But disclosure isn’t the same as dosing-for-effect, and here the gap is specific and checkable: the gummy’s ashwagandha dose is half the capsule’s and a quarter of the dose used in the one positive trial behind that ingredient, the black cohosh dose matches research norms for an ingredient that research has largely failed to validate, and the chasteberry is doing a job it has no menopause-specific evidence for doing. Wide retail distribution and a loyal TikTok following are marketing facts, not efficacy facts. If you’re going to try it, the capsules are the more evidence-aligned format on the one ingredient that has a real trial behind it — but “more evidence-aligned” is a long way from “proven.”

FAQ

Is O Positiv MENO the same as O Positiv FLO?
No. FLO is O Positiv’s PMS and ovarian-support product aimed at reproductive-age women with regular cycles. MENO is the separate menopause-targeted line.

Do the MENO capsules and gummies work the same way?
Not quite. Black cohosh, chasteberry, B6 and D3 are dosed identically in both, but the gummy’s ashwagandha dose is half the capsule’s — 150 mg versus 300 mg per day.

Is chasteberry proven to help with menopause symptoms?
No. Chasteberry’s clinical evidence is for PMS and cyclical breast pain in younger, cycling women. The one study that tested it specifically for menopausal symptoms found no benefit.

Sources